Jennifer K Mulligan

Jennifer K Mulligan, PhD

Associate Professor

Department: MD-OTOLARYNGOLOGY
Business Phone: (352) 273-8737

Teaching Profile

Courses Taught
2023-2024
GMS6847 Translational Research and Therapeutics: Bench, Bedside, Community, & Policy

Publications

2023
All chronic rhinosinusitis endotype clusters demonstrate improvement in patient-reported and clinical outcome measures after endoscopic sinus surgery.
International forum of allergy & rhinology. [DOI] 10.1002/alr.23255. [PMID] 37563836.
2022
Modulating donor mitochondrial fusion/fission delivers immunoprotective effects in cardiac transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 22(2):386-401 [DOI] 10.1111/ajt.16882. [PMID] 34714588.
2022
Role of C3a as a Novel Regulator of 25(OH)D3 to 1α,25-Dihydroxyvitamin D3 Metabolism in Upper Airway Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950). 209(2):262-269 [DOI] 10.4049/jimmunol.2000726. [PMID] 35793909.
2022
Sinonasal IgG4-related sclerosing disease: A rare entity and challenging diagnosis.
Laryngoscope investigative otolaryngology. 7(6):1725-1732 [DOI] 10.1002/lio2.944. [PMID] 36544949.
2022
Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis.
American journal of rhinology & allergy. 36(6):872-883 [DOI] 10.1177/19458924221111830. [PMID] 35848564.
2021
Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants.
Children (Basel, Switzerland). 8(10) [DOI] 10.3390/children8100879. [PMID] 34682144.
2021
Editorial: Autoimmunity and Chronic Inflammation in Early Life.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.761160. [PMID] 34567015.
2021
Effects of vitamin D supplementation on circulating concentrations of growth factors and immune-mediators in healthy women during pregnancy.
Pediatric research. 89(3):554-562 [DOI] 10.1038/s41390-020-0885-7. [PMID] 32311700.
2021
Endotyping chronic rhinosinusitis based on olfactory cleft mucus biomarkers.
The Journal of allergy and clinical immunology. 147(5):1732-1741.e1 [DOI] 10.1016/j.jaci.2021.01.021. [PMID] 33549569.
2021
Olfactory cleft mucus inflammatory proteins in CRS: a case-control study.
International forum of allergy & rhinology. 11(9):1321-1335 [DOI] 10.1002/alr.22770. [PMID] 33629532.
2021
Olfactory cleft mucus proteome in chronic rhinosinusitis: a case-control pilot study.
International forum of allergy & rhinology. 11(8):1162-1176 [DOI] 10.1002/alr.22743. [PMID] 33275311.
2020
A Community-Based Study on the Prevalence of Olfactory Dysfunction.
American journal of rhinology & allergy. 34(5):661-670 [DOI] 10.1177/1945892420922771. [PMID] 32345032.
2020
Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis.
International forum of allergy & rhinology. 10(3):343-355 [DOI] 10.1002/alr.22499. [PMID] 31856395.
2019
Contribution of Epithelial Cell Dysfunction to the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps.
American journal of rhinology & allergy. 33(6):782-790 [DOI] 10.1177/1945892419868588. [PMID] 31382760.
2019
Olfactory cleft mucus proteins associated with olfactory dysfunction in a cohort without chronic rhinosinusitis.
International forum of allergy & rhinology. 9(10):1151-1158 [DOI] 10.1002/alr.22391. [PMID] 31442006.
2018
C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.
Mucosal immunology. 11(5):1375-1385 [DOI] 10.1038/s41385-018-0048-x. [PMID] 29907871.
2018
Glucocorticoid receptor isoform expression in peripheral blood mononuclear leukocytes of patients with chronic rhinosinusitis.
International forum of allergy & rhinology. [DOI] 10.1002/alr.22120. [PMID] 29719127.
2018
Impact of Mitochondrial Permeability on Endothelial Cell Immunogenicity in Transplantation.
Transplantation. 102(6):935-944 [DOI] 10.1097/TP.0000000000002163. [PMID] 29538260.
2018
Novel Radiographic Assessment of the Cribriform Plate.
American journal of rhinology & allergy. 32(3):175-180 [DOI] 10.1177/1945892418768159. [PMID] 29660990.
2017
Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.
PloS one. 12(10) [DOI] 10.1371/journal.pone.0186374. [PMID] 29045457.
2017
Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells.
International forum of allergy & rhinology. 7(8):777-785 [DOI] 10.1002/alr.21955. [PMID] 28574651.
2017
Induction of CFTR gene expression by 1,25(OH)2 vitamin D3, 25OH vitamin D3, and vitamin D3 in cultured human airway epithelial cells and in mouse airways.
The Journal of steroid biochemistry and molecular biology. 173:323-332 [DOI] 10.1016/j.jsbmb.2017.01.013. [PMID] 28130182.
2017
Sinonasal T-cell expression of cytotoxic mediators granzyme B and perforin is reduced in patients with chronic rhinosinusitis.
American journal of rhinology & allergy. 31(6):352-356 [DOI] 10.2500/ajra.2017.31.4474. [PMID] 29122079.
2017
The Link Between Cytokine Levels and Loss of Olfaction in Chronic Rhinosinusitis-Reply.
JAMA otolaryngology– head & neck surgery. 143(2):195-196 [DOI] 10.1001/jamaoto.2016.2427. [PMID] 27585408.
2017
The role of regulatory T cells in the regulation of upper airway inflammation.
American journal of rhinology & allergy. 31(6):345-351 [DOI] 10.2500/ajra.2017.31.4472. [PMID] 29122078.
2016
Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity.
International forum of allergy & rhinology. 6(2):162-8 [DOI] 10.1002/alr.21636. [PMID] 26370180.
2016
Mucous Cytokine Levels in Chronic Rhinosinusitis-Associated Olfactory Loss.
JAMA otolaryngology– head & neck surgery. 142(8):731-7 [DOI] 10.1001/jamaoto.2016.0927. [PMID] 27228459.
2016
Reduced sinonasal levels of 1α-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps.
International forum of allergy & rhinology. 6(1):58-65 [DOI] 10.1002/alr.21576. [PMID] 26575398.
2016
Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
International forum of allergy & rhinology. 6(6):605-10 [DOI] 10.1002/alr.21704. [PMID] 26750566.
2015
Relationship between Targeting Efficacy of Liposomes and the Dosage of Targeting Antibody Using Surface Plasmon Resonance.
Langmuir : the ACS journal of surfaces and colloids. 31(44):12177-86 [DOI] 10.1021/acs.langmuir.5b01386. [PMID] 26484937.
2015
Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis.
American journal of rhinology & allergy. 29(2):89-93 [DOI] 10.2500/ajra.2015.29.4155. [PMID] 25785747.
2015
Vitamin D for the treatment of respiratory diseases: is it the end or just the beginning?
The Journal of steroid biochemistry and molecular biology. 148:326-37 [DOI] 10.1016/j.jsbmb.2015.01.017. [PMID] 25625665.
2015
Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis.
International forum of allergy & rhinology. 5(3):191-6 [DOI] 10.1002/alr.21474. [PMID] 25561293.
2014
Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis.
The Journal of allergy and clinical immunology. 134(2):342-9 [DOI] 10.1016/j.jaci.2014.01.039. [PMID] 24698317.
2014
Impact of intraoperative hydrodebrider treatment on postoperative sinonasal inflammation.
American journal of rhinology & allergy. 28(5):438-42 [DOI] 10.2500/ajra.2014.28.4073. [PMID] 25198033.
2014
Impact of vitamin D deficiency upon clinical presentation in nasal polyposis.
International forum of allergy & rhinology. 4(3):196-9 [DOI] 10.1002/alr.21274. [PMID] 24415576.
2014
Macrophage Infiltrate Is Elevated in CRSwNP Sinonasal Tissue Regardless of Atopic Status.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 151(2):215-20 [DOI] 10.1177/0194599814528672. [PMID] 24705220.
2014
Passive smoke exposure in chronic rhinosinusitis as assessed by hair nicotine.
American journal of rhinology & allergy. 28(4):297-301 [DOI] 10.2500/ajra.2014.28.4058. [PMID] 25197916.
2014
Systemic monocyte-derived dendritic cells and associated Th2 skewing in chronic rhinosinusitis.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 150(2):312-20 [DOI] 10.1177/0194599813516277. [PMID] 24367054.
2013
Characterization of B-cell subpopulations in patients with chronic rhinosinusitis.
International forum of allergy & rhinology. 3(8):621-9 [DOI] 10.1002/alr.21173. [PMID] 23640795.
2013
Cytokine correlation between sinus tissue and nasal secretions among chronic rhinosinusitis and controls.
The Laryngoscope. 123(12):E72-8 [DOI] 10.1002/lary.24305. [PMID] 23852962.
2013
Differential expression of adhesion molecules by sinonasal fibroblasts among control and chronic rhinosinusitis patients.
American journal of rhinology & allergy. 27(5):381-6 [DOI] 10.2500/ajra.2013.27.3934. [PMID] 24119601.
2013
Reactive oxygen species in chronic rhinosinusitis and secondhand smoke exposure.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 149(4):633-8 [DOI] 10.1177/0194599813496377. [PMID] 23838308.
2012
Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 147(4):773-81 [PMID] 22627120.
2011
Human sinonasal epithelial cells direct dendritic function and T-cell T helper 1/T helper 2 skewing following Aspergillus exposure.
International forum of allergy & rhinology. 1(4):268-74 [DOI] 10.1002/alr.20055. [PMID] 22287430.
2011
Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis.
International forum of allergy & rhinology. 1(4):296-302 [DOI] 10.1002/alr.20046. [PMID] 22287435.
2011
Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis.
Clinical and experimental immunology. 164(3):312-20 [DOI] 10.1111/j.1365-2249.2011.04325.x. [PMID] 21401575.
2010
Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 143(1):152-8 [DOI] 10.1016/j.otohns.2010.02.022. [PMID] 20620635.
2010
Tumor secretion of VEGF induces endothelial cells to suppress T cell functions through the production of PGE2.
Journal of immunotherapy (Hagerstown, Md. : 1997). 33(2):126-35 [DOI] 10.1097/CJI.0b013e3181b91c9c. [PMID] 20145550.
2010
Tumors induce the formation of suppressor endothelial cells in vivo.
Cancer immunology, immunotherapy : CII. 59(2):267-77 [DOI] 10.1007/s00262-009-0747-y. [PMID] 19669642.
2009
Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions.
Human immunology. 70(6):375-82 [DOI] 10.1016/j.humimm.2009.01.014. [PMID] 19480853.
2008
Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice.
Journal of the American Association for Laboratory Animal Science : JAALAS. 47(2):16-23 [PMID] 18351717.
2008
Tumors skew endothelial cells to disrupt NK cell, T-cell and macrophage functions.
Cancer immunology, immunotherapy : CII. 57(7):951-61 [PMID] 18058097.

Grants

Nov 2023 ACTIVE
Initiation of immune responses to SARS COV2 in the oral cavity and upper airway
Role: Principal Investigator
Funding: TULANE UNIV. via NATL INST OF HLTH NIDCR
Apr 2022 ACTIVE
Initiation of immune e responses to SARS COV2 in the oral cavity and upper airway
Role: Principal Investigator
Funding: UNIVIVERSITY OF MISSISSIPPI MEDICAL CTR via NATL INST OF HLTH NIDCR
Apr 2021 ACTIVE
Role of Vitamin D Metabolism in CRS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2021 ACTIVE
Epithelial cell complement production in the pathogenesis of chronic rhinosinusitis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Oct 2020 – Jun 2021
Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis
Role: Principal Investigator
Funding: MEDICAL UNIV OF SOUTH CAROLINA via NATL INST OF HLTH NIDCD
Oct 2020 – Dec 2020
Epithelial cell complement production in the pathogenesis of chronic rhinosinusitis
Role: Principal Investigator
Funding: MEDICAL UNIV OF SOUTH CAROLINA via NATL INST OF HLTH NIAID

Contact Details

Phones:
Business:
(352) 273-8737
Emails:
Addresses:
Business Mailing:
PO Box 100275
GAINESVILLE FL 32610