Carolyn O Dirain

Carolyn O Dirain, Ph.D

Research Scientist

Department: MD-OTOLARYNGOLOGY
Business Phone: (352) 273-5199

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-0203-8323

Publications

2021
Effects of quinolone and poloxamer otic suspension on rat tympanic membranes.
International journal of pediatric otorhinolaryngology. 147 [DOI] 10.1016/j.ijporl.2021.110805. [PMID] 34175658.
2021
Efficacy of Topical Epinephrine in Tympanoplasty
The Laryngoscope. 131(10):2319-2322 [DOI] 10.1002/lary.29688.
2020
Cytotoxicity of Ear Drop Excipients in Human and Mouse Tympanic Membrane Fibroblasts.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 162(2):204-210 [DOI] 10.1177/0194599819889701. [PMID] 31791190.
2020
Rat Model of External Auditory Canal Stenosis.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 41(7):e876-e880 [DOI] 10.1097/MAO.0000000000002668. [PMID] 32658405.
2020
The Effects of Steroids on Survival of Mouse and Human Tympanic Membrane Fibroblasts.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 163(2):382-388 [DOI] 10.1177/0194599820912739. [PMID] 32204660.
2019
Commercial Quinolone Ear Drops Cause Perforations in Intact Rat Tympanic Membranes.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 40(10):1386-1391 [DOI] 10.1097/MAO.0000000000002371. [PMID] 31592822.
2019
Microbiome Analysis of Cholesteatoma by Gene Sequencing.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 40(9):1186-1193 [DOI] 10.1097/MAO.0000000000002355. [PMID] 31469791.
2019
Response to the Letter to the Editor: “Ciprofloxacin Otic Suspension and Permanent Peripheral Neuropathy”.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 160(1) [DOI] 10.1177/0194599818805729. [PMID] 30798744.
2018
Cytotoxicity of Ciprofloxacin and Steroids in Mouse Tympanic Membrane Fibroblasts.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 158(3):547-552 [DOI] 10.1177/0194599817751093. [PMID] 29336207.
2018
Effects of Common Ear Drops on Tympanic Membrane Healing in Rats.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 158(5):917-922 [DOI] 10.1177/0194599818757972. [PMID] 29460666.
2018
Efficacy of common reagents for killing ticks in the ear canal
Laryngoscope Investigative Otolaryngology. 3(6):492-495 [DOI] 10.1002/lio2.217. [PMID] 30599035.
2018
Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 39(1):111-118 [DOI] 10.1097/MAO.0000000000001638. [PMID] 29194212.
2018
Predictors of returns to the emergency department after head and neck surgery.
Head & neck. 40(3):498-511 [DOI] 10.1002/hed.25019. [PMID] 29240278.
2018
Prevention of Chlorhexidine Ototoxicity With Poloxamer in Rats.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 39(8):e738-e742 [DOI] 10.1097/MAO.0000000000001920. [PMID] 30113566.
2017
Collagen and α-Tubulin of Mouse Tympanic Membrane Fibroblasts Treated with Quinolones and Aminoglycosides.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 156(2):341-349 [DOI] 10.1177/0194599816672627. [PMID] 27677596.
2017
Microflora of Retained Intracochlear Electrodes from Infected Cochlear Implants.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 157(1):85-91 [DOI] 10.1177/0194599817693228. [PMID] 28195822.
2017
Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 156(3):543-548 [DOI] 10.1177/0194599816678381. [PMID] 28248600.
2017
The Adenoid Microbiome in Recurrent Acute Otitis Media and Obstructive Sleep Apnea.
The journal of international advanced otology. 13(3):333-339 [DOI] 10.5152/iao.2017.4203. [PMID] 29360088.
2016
Ciprofloxacin Decreases Collagen in Mouse Tympanic Membrane Fibroblasts.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 155(1):127-32 [DOI] 10.1177/0194599816633671. [PMID] 26932971.
2016
Prevention of biofilm formation by polyquaternary polymer.
International journal of pediatric otorhinolaryngology. 88:157-62 [DOI] 10.1016/j.ijporl.2016.07.004. [PMID] 27497405.
2015
Assessment of mitochondrial membrane potential in HEI-OC1 and LLC-PK1 cells treated with gentamicin and mitoquinone.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 152(4):729-33 [DOI] 10.1177/0194599814564934. [PMID] 25550222.
2013
Biofilm formation on coated silicone tympanostomy tubes.
International journal of pediatric otorhinolaryngology. 77(2):223-7 [DOI] 10.1016/j.ijporl.2012.10.027. [PMID] 23200869.
2013
Efficacy of disinfecting solutions in removing biofilms from polyvinyl chloride tracheostomy tubes.
The Laryngoscope. 123(1):259-63 [DOI] 10.1002/lary.23612. [PMID] 22887035.
2012
Effectiveness of pediatric tracheostomy tube cleaning.
Archives of otolaryngology–head & neck surgery. 138(3):251-6 [DOI] 10.1001/archoto.2011.1133. [PMID] 22351853.
2012
Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone.
The Laryngoscope. 122(11):2543-8 [DOI] 10.1002/lary.23593. [PMID] 22965463.
2012
Tympanostomy tube in vitro biofilm potential of common otopathogens.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 146(5):816-22 [DOI] 10.1177/0194599811435781. [PMID] 22371343.
2011
Biofilm formation on silicone tympanostomy tubes with polyvinylpyrrolidone coating.
Archives of otolaryngology–head & neck surgery. 137(1):19-23 [DOI] 10.1001/archoto.2010.205. [PMID] 21242541.
2011
Pseudomonas biofilm formation after Haemophilus infection.
Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 145(3):470-5 [DOI] 10.1177/0194599811405285. [PMID] 21493260.
2011
Topical antibiotic treatment reduces tympanostomy tube biofilm formation.
The Laryngoscope. 121(5):1067-71 [DOI] 10.1002/lary.21748. [PMID] 21437915.
2010
Adeno-Associated Virus-Mediated Knockdown of Pyruvate Dehydrogenase E1 Alpha in Specific Regions of the Rat Brain
Mitochondrion. 10 [DOI] 10.1016/j.mito.2009.12.01.
2010
An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.
Molecular genetics and metabolism. 101(2-3):183-91 [DOI] 10.1016/j.ymgme.2010.07.008. [PMID] 20685142.
2009
AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.
Molecular genetics and metabolism. 98(3):289-99 [DOI] 10.1016/j.ymgme.2009.05.010. [PMID] 19586787.
2009
Adeno-Associated Virus-Mediated Knockdown of Pyruvate Dehydrogenase E1F(N)Over-Tilde At in in Specific Regions of the Rat Brain
Molecular Genetics and Metabolism. 98
2009
High-Efficiency Transduction of Human Hepatoblastoma and Hepatocellular Carcinoma Cells By the Wild-Type and the Tyrosine-Mutant Aav3 Serotype Vectors
Molecular Therapy. 17

Grants

Sep 2021 ACTIVE
Phase IIA Trial of Dichloroacetate for Glioblastoma Multiforme, IND137007, 09172019
Role: Project Manager
Funding: US FOOD AND DRUG ADMN
Dec 2020 ACTIVE
Rapid olfactory tools for telemedicine-friendly COVID-19 screening and surveillance
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jun 2020 – Jun 2021
Ototoxicity of Next Science Middle Ear Wash in guinea pigs with otitis media
Role: Principal Investigator
Funding: NEXT SCIENCE LLC
Mar 2018 – Nov 2018
Ototoxicity of a Novel Antimicrobial Solution – #2
Role: Co-Investigator
Funding: NEXT SCIENCE LLC
Nov 2017 – Jun 2018
Ototoxicity of a novel antimicrobial solution
Role: Co-Investigator
Funding: NEXT SCIENCE LLC
Aug 2017 ACTIVE
Optimizing AAV Vectors for Central Nervous System transduction
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Apr 2015 – Feb 2018
Microbiome analysis of middle ear atelectasis and cholesteatoma by gene pyrosequencing
Role: Principal Investigator
Funding: MEDTRONIC INC XOMED
Dec 2013 – May 2016
MitoQ as novel agent for protecting against aminoglycoside ototoxicity
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDCD

Contact Details

Phones:
Business:
(352) 273-5199
Addresses:
Business Mailing:
PO Box 100264
GAINESVILLE FL 32610